Healthy Glucose Support

• Helps maintain healthy blood glucose levels by supporting sugar and carbohydrate metabolism. 

Healthy Cholesterol

• May help to maintain healthy cholesterol in healthy individuals and support cardiovascular system health

Healthy Metabolic Function

• Supports healthy metabolic function

1️⃣ Healthy Blood Glucose Support

• In a double-blind randomized controlled trial, Yin et al. (2008) demonstrated that 1500 mg per day of berberine significantly reduced fasting plasma glucose and HbA1c levels while improving insulin sensitivity in adults with type II diabetes. The effects were comparable to metformin over a three-month period.
• A 2021 meta-analysis by Zhang et al. further confirmed that berberine supplementation at doses ranging from 900–1,500 mg per day significantly reduced fasting plasma glucose, HbA1c, and HOMA-IR across mixed populations. These findings provide strong evidence for glycemic control, supporting a maintenance positioning at 550 mg taken once or twice daily for dietary supplement use.

2️⃣ Metabolic Function Support

• Wei et al. (2025) conducted a meta-analysis of 20 randomized controlled trials involving adults with metabolic syndrome and found that berberine supplementation at doses of 500–1,500 mg per day significantly reduced waist circumference, triglycerides, LDL cholesterol, and fasting glucose, demonstrating broad metabolic improvements.
• Similarly, a 12-week randomized controlled trial by Zhang Q et al. (2020) showed that 1,000 mg per day of berberine significantly reduced body mass index and waist circumference while improving both lipid and glucose markers in adults with metabolic syndrome.

3️⃣ Healthy Cholesterol and Lipid Metabolism

• In a double-blind randomized controlled trial, Kong et al. (2004) found that 1,000 mg per day of berberine reduced LDL cholesterol by 25%, lowered triglycerides, and increased HDL cholesterol in adults with mild hyperlipidemia, demonstrating strong lipid modulation.
• A 2012 meta-analysis by Dong et al., which included 11 randomized controlled trials, confirmed that berberine supplementation at 900–1,500 mg per day significantly reduced total cholesterol, LDL cholesterol, and triglycerides across mixed populations.

4️⃣ Sugar and Carbohydrate Metabolism

• Zhang H et al. (2010) reported in a randomized controlled trial that 1,500 mg per day of berberine significantly reduced insulin resistance, as measured by HOMA-IR, and improved glucose uptake in adults with insulin resistance.
• In addition, a narrative review by Cicero et al. (2021) summarized clinical trial data showing that berberine at doses of 1,000–1,500 mg per day reduced postprandial glucose levels and improved insulin signaling, supporting its role in modulating carbohydrate digestion and metabolism.

5️⃣ Comprehensive Metabolic Health

• An overview of 54 systematic reviews conducted by Fu et al. (2025) found consistent evidence that berberine supplementation at 900–1,500 mg per day improves blood glucose control, lipid profiles, body mass index, and waist circumference across multiple chronic disease populations, including type 2 diabetes, metabolic syndrome, and NAFLD.
• Additionally, Zhang et al. (2021), in a meta-analysis of 46 randomized controlled trials, reported significant reductions in fasting glucose, LDL cholesterol, triglycerides, and body mass index, reinforcing the broad metabolic benefits of berberine supplementation.

Take one capsule 1-2 times daily with food.

After use, return your empty pouch using the prepaid envelope provided. Through our composting partner, Circular Cube Composting Company, packaging is processed to reduce plastic waste.